Douglas Frey

CAST FACULTY

Professor, UMBC and CAST Collaborator

Douglas Frey is a Collaborator, Center for Advanced Sensor Technology and a Professor, Department of Chemical and Biochemical Engineering University of Maryland, Baltimore County.

KNOWN FOR

Chromatofocusing Protein Purification Bioseparations

Email Lab Website

Signature Work ↓ Publications ↓

SIGNATURE WORK

Global Impact

01 PROTEIN PURIFICATION

Chromatofocusing

A column method that separates proteins by their isoelectric point, using a pH gradient that forms inside the column on its own. He co-wrote the Encyclopedia of Life Sciences entry on the method.

Genzyme worked with his lab on scale-up

02 SAFER BIOLOGICS

Virus Removal

Chromatography steps that pull viruses out of protein drugs during manufacturing. His group has studied how well these steps remove viruses, and has used chromatofocusing to separate bacteriophages.

Required safety step for protein drugs made in animal cells

Virus particles captured during purification

The CAST team with the Mini-BioMOD system at the FDA

03 MEDICINES ON DEMAND

Point-of-Care Protein Drugs

He co-authored the 2018 Nature Biomedical Engineering study showing that a small, portable system can make protein drugs of good-manufacturing-practice quality, with purification built into the process.

GMP quality protein drugs made where patients are

COURSES HE TEACHES

ENCH 427: Heat and Mass Transfer ENCH 445: Separation Processes ENCH 485L: Biochemical Engineering Laboratory ENCH 610: Chemical Engineering Thermodynamics ENCH 630: Transport Phenomena