Membrane bioreactors for recombinant protein synthesis

Adequate gaseous exchange, providing enough oxygen to the respiring cells or cell-free system, and removing accumulating carbon dioxide has always been a challenge. Our work addresses this issue by replacing the steel and glass walls of these bioreactors with engineered membranes which can selectively allow these gaseous substrates to flow through them, thus, reducing the oxygen and carbon dioxide tension in these systems. We are designing and exploring different variants of biocompatible silicone membranes to achieve an expertise in developing membrane platform bioreactors for cell-based and cell-free recombinant protein synthesis.