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Leah Tolosa

Leah Tolosa is an Assistant Director, Center for Advanced Sensor Technology Research and an Research Associate Professor, Department of Chemical & Biochemical Engineering University of Maryland, Baltimore County.


leah@umbc.edu
Title: Research Associate Professor

Education

University of Santo Tomas Chemistry B.S. 1980
University of Santo Tomas Chemistry M.S. 1987
University of Connecticut Chemistry Ph.D. 1995
Brandeis University Photochemistry 1994-1996 (post-doc)
Appointments

Assistant Director, Center for Advanced Sensor Technology, UMBC 2004- present
Research Associate Prof., Department of Chem. & Biochem. Engg.,UMBC 2006- present
Research Asst. Prof., Dept. of Chemical & Biochemical Engineering, UMBC 2001-2006
Research Assoc., Center for Fluorescence Spectroscopy, U. Maryland Baltimore 1996-2001
Research Activities

Participant in Scientific Review Panels for the National Institute of Diabetes and Digestive and Kidney Diseases: Develop new therapies for Type 1 diabetes and its complications (July 30, 2004) and Small Business Bioengineering and Physiology (March 13 – 14, 2006, April 4, 2007).
Participant in the Scientific Review Panel for the US Army Research and Materiel Command: Technologies in Metabolic Monitoring (April 10 – 12, 2005).
Participant in Review Panel for the National Science Foundation Integrative Graduate Education Research and Traineeship Program (June 18 – 19, 2007).
Initiated collaborations between the UMBC Center for Advanced Sensor Technology and the UM Greenebaum Cancer Center, UMBC Center for Advanced Studies in Photonics Research, US Department of Agriculture, Spectrx, Inc., the Sensor Group of the University of Santo Tomas, Manila and the Chemistry Department at the University of the Philippines.
An active member of the Philippine-American Academy of Science and Engineering, served as Secretary from 2000 – 2005, Member of the Board of Directors from 2006 – 2008, and Vice-President, President- Elect 2007. I was a major participant in organizing the PAASE annual meetings both here in the US and in the Philippines.
Active participant and member of the Oversight Committee of the NIH Network for Minority Research Investigators.
An active reviewer of manuscripts submitted to leading scientific journals and grant proposals submitted to agencies such as the Maryland Industrial Partnerships.
Awards and memberships

2003 – 2006: Principal Investigator, Mentored Quantitative Research Career Development Award (K25DK062990) from the National Institutes of Health
2004-2007: Principal Investigator, Technologies for Metabolic Monitoring (W81XWH-04-1-0781) from the US Army Medical Research and Materiel Command
2005-2010: Principal Investigator, Research Project Grant (R01DK072465-01) from the National Institutes of Health
Selected publications

Tolosa, L. M., Malak, H., Rao, G. and Lakowicz, J. R., (1997) Optical Assay for Glucose Based on the Luminescence Decay Time of the Long Wavelength Dye Cy5TM , Sensors and Actuators B, 45, 93-99.
Tolosa, L. M., Szmacinski, H., Rao, G. and Lakowicz, J. R. (1997) Lifetime-based Sensing of Glucose Using Energy Transfer with a Long Lifetime Donor, Analytical Biochemistry, 250, 102-108.
Tolosa, L., Ge, X., Rao, G. (2004) Dual-labeled Glucose Binding Protein for Ratiometric Measurements of Glucose. Anal. Chem. 76:1403-1410.
Ge, X., Tolosa, L., Simpson, J., Rao, G. (2003) Genetically engineered binding proteins as biosensors for fermentation and cell culture, Biotech. Bioeng., 84, 723-731.
Tolosa, L., Ge, X., Rao, G. Reagentless optical sensing of glutamine using a dual-emitting glutamine binding protein. 2003. Anal. Biochem. 314:199-205.
Tolosa, L., Kostov, Y., Harms, P., Rao, G. (2002) Non-invasive measurement of dissolved oxygen in shake flasks, Biotech. Bioeng., 80, 594-597.
Tolosa, L., Gryczynski, I., Eichorn, L., Dattelbaum, J., Castellano, F. N., Rao, G. and Lakowicz, J. R.,(1999) Glucose Sensor for Low Cost Lifetime-Based Sensing Using a Genetically Engineered Protein, Anal. Biochem., 267(1), 114-120.
Bartolome, A., Bardliving, C., Rao, G., Tolosa, L. (2005) Fatty acid sensor for low-cost lifetime-assisted ratiometric sensing using a fluorescent fatty acid binding protein, Anal. Biochem., 345, 133-139.